I'd be interested in something that goes all the way to the heads (includes injector boss, lets you use factory fuel rails, this requires two different PN# for the top feeds and side feeds) and shifts power to higher rpm slightly, maybe 500-1000rpm. .
Trying to keep TGVs is passe and unnecessary. The CELs can be reflashed out for free now and there is practically no downside. If you're going to make a new intake manifold, it might as well go straight to the head.
I don't see any reason not to place the throttle body at the same position. I also don't see why you wouldn't make it work both directions. Including a pipe or hose that is workable for running reversed and with AC would be a nice touch. It is usually pretty tight, so making something that gets the pipe over the alternator and then can be adapted as needed would be nice. There's plenty of room in front of the engine for each user to adjust their piping by buying a few couplers, cutting their existing pipe, etc.
I'm sure there are tons of people with 400-550hp large bolt-on or rotated turbos itching at the bit to get an aftermarket manifold that posts power gains.