For me there are two empirical differences between a 2 and 4 door.
2 door: The B pillar *can* be set back further allowing for more comfortable arm out the window driving. This is countered by overly long doors leading to a more difficult egress and ingress. This also means possibly more chipping them.
4 door: Far more practical. I almost never have to use my trunk to carry groceries (they tend to move a lot more in the trunk than the back seat). I carry a toolbox behind my driver's seat and access to it would be that much more difficult in a 2 door.
Aesthetics are pointless to argue unless we're comparing an Aztek to an Italia.