We sold our Ford E250 in2005 and it ran alike a champ with 165000 on it. I'd towed up to 5500 lb sailboat trailers and had made a number of runs MA to Fl and return. We replaced the radiator, the brakes, and were on the 3rd set of rear Michelin LTX tires. 35 gallon tank so you can tow for 5-8 hours easy.
We replaced it with a Chevy Express 2500 that runs perfectly at 121000 miles. I know folks who have put 300000 on them.
But $2K is an awfully tight budget. D or E load rating tires are close to $200 each and a brake job is a lot more than a car.